Glutamate carboxypeptidase 2 , also known as Glutamate carboxypeptidase II , Membrane glutamate carboxypeptidase , Prostate-specific membrane antigen , GCPII , PSMA , FOLH1 , and NAALAD1 , is a single-pass type II membrane protein which belongs to thepeptidase M28 family and M28B subfamily. FOLH1 is highly expressed in prostate epithelium. It is detected in urinary bladder , kidney , testis , ovary , fallopian tube , breast , adrenal gland , liver , esophagus , stomach , small intestine , colon , brain (at protein level) , and the capillary endothelium of a variety of tumors. FOLH1 has both folate hydrolase and N-acetylated alpha linked acidic dipeptidase (NAALADase) activity. It has a preference for tri-alpha-glutamate peptides. Genetic variation in FOLH1 may be associated with low folate levels and consequent hyperhomocysteinemia. This condition can result in increased risk of cardiovascular disease , neural tube defects , and cognitive deficits. FOLH1 also shows a promising role in directed imaging and therapy of recurrent or metastatic disease.

Codice: PDMH100295_20μg | Marca: Elabscience | Confezionamento: 20μg