Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation.

Dettagli prodotto

• Codice: PDMH100324_500μg
• Marca: Elabscience
• Specie target: Human
• Host: Mammalian
• Confezionamento: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
• Link: Apri link
• Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
• Simbolo target: ICOSL
• Ig target: B7H;B7-H;B7 Homolog;B7-Like Protein Gl;B7-Related Protein;V-Set and Immunoglobulin Domain-Containing Protein;KIAA;VSIG;ICOSLG;B7-H2;B7H2;B7RP-1;B7RP1;CD275;GL50;ICOS-L;ICOSL;LICOS;B7 Homolog 2;B7-Like Protein Gl50;B7-Related Protein 1;ICOS Ligand;Protein Z39Ig;V-Set and Immunoglobulin Domain-Containing Protein 4;VSIG4;Z39IG;CRIg;KIAA0653; ICOSL; B7RP1; B7h;B7 H2;B7 homologue 2;B7 like protein Gl50;B7 related protein 1;B7RP 1;CD 275;CD275 antigen;GL 50;ICOS L;ICOS LG;Inducible T cell co stimulator ligand;Transmembrane protein B7 H2 ICOS ligand
• Area di ricerca: Immunology