Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).

Dettagli prodotto

• Codice: PDMM100100_1mg
• Marca: Elabscience
• Specie target: Mouse
• Host: Mammalian
• Confezionamento: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
• Link: Apri link
• Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
• Simbolo target: Ctla4 CD152
• Ig target: ALPS5;CD 152;CD;CD152;CD152 antigen;CD152 isoform;Celiac disease 3;CELIAC3;CTLA 4;CTLA-4;CTLA4;CTLA4;Cytotoxic T cell associated 4;Cytotoxic T lymphocyte antigen 4;Cytotoxic T lymphocyte associated 4;Cytotoxic T lymphocyte associated 4;soluble isoform;included;Cytotoxic T lymphocyte associated antigen 4;Cytotoxic T lymphocyte associated antigen 4 short spliced form;Cytotoxic T lymphocyte associated protein 4;Cytotoxic T lymphocyte associated serine esterase 4;Cytotoxic T lymphocyte protein 4;Cytotoxic T-lymphocyte protein 4;Cytotoxic T-lymphocyte-associated antigen 4;GRD4;GSE;ICOS;IDDM12;insulin-dependent diabetes mellitus 12;Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4;OTTHUMP00000216623
• Area di ricerca: Cancer;Immunology;Stem cells