FANCA is one of the six known Fanconi anemia gene products (FANCA, FANCC, FANCD2, FANCE, FANCF, and FANCG proteins). Fanconi anemia (FA) is a genetic disorder predisposing to aplastic anemia and cancer characterized by hypersensitivity to DNA-damaging agents and oxidative stress. FANCA associates with the IκB kinase (IKK) signalsome via interaction with IKK2. Components of the FANCA complex undergo rapid, stimulus-dependent changes in phosphorylation, which are blocked by kinase-inactive IKK2.

Dettagli prodotto

• Codice: PKSH030946_100μg
• Marca: Elabscience
• Specie target: Human
• Host: Baculovirus-Insect Cells
• Confezionamento: Lyophilized from sterile 20mM Tris, 200mM NaCl, pH 8.5, 20% glycerol, 0.1% Triton, 1mM TCEP<br/>Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.
• Link: Apri link
• Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
• Ig target: FA;FA-H;FA1;FAA;FACA;FAH;FANCH
• Area di ricerca: Epigenetics and Nuclear Signaling