Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis.

Codice: PKSH032479_10μg | Marca: Elabscience | Confezionamento: 10μg

Specie: Human

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Codice: PKSH032479_10μg
Marca: Elabscience
Specie target: Human
Host: E.coli
Confezionamento: Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4.
Link: Apri link
Stoccaggio: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Simbolo target: Gankyrin;PSDM10
Ig target: 26S Proteasome Non-ATPase Regulatory Subunit 10;26S Proteasome Regulatory Subunit p28;Gankyrin;PSMD10;p28(GANK)
Area di ricerca: Cell biology;Cancer

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