Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha; it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis; and produced by rheumatoid arthritis synovium. It increases IL-6 production; induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

Dettagli prodotto

• Codice: PKSH032620_20μg
• Marca: Elabscience
• Specie target: Human
• Host: E.coli
• Confezionamento: Lyophilized from sterile PBS,pH 8.0.<br/>Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.
• Link: Apri link
• Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
• Applicazione: Cell culture
• Simbolo target: Interleukin-17A;IL-17A
• Ig target: Cytotoxic T-lymphocyte-associated antigen;IL17A;CTLA-8;CTLA8;IL-17;IL-17A;IL17;Interleukin-17A;Cytotoxic T-lymphocyte-associated antigen 8;CTLA 8;CTLA8;CTLA-8;CTLA8cytotoxic T-lymphocyte-associated serine esterase 8;Cytotoxic T-lymphocyte-associated antigen 8;IL17;IL-17;IL17A;IL-17A;IL-17Acytotoxic T-lymphocyte-associated protein 8;IL-17CTLA-8;Cytotoxic T lymphocyte associated antigen 8;Cytotoxic T lymphocyte associated protein 8;Cytotoxic T lymphocyte associated serine esterase 8;IL 17A;Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8);Interleukin 17A;Interleukin17;Interleukin17A;OTTHUMP00000016597;OTTMUSP00000046003
• Area di ricerca: Cancer;immunology