Human Interleukin-36 Receptor Antagonist (IL-36RN) is a secreted protein which belongs to the Interleukin 1 cytokine family (IL-1 family). IL-36RN is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. IL-36RN is also detected in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. IL-36RN is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to Interleukin 1 family member 9 (IL1F9). Dysregulated expression of novel agonistic and antagonistic IL-1 family member ligands can promote cutaneous inflammation, revealing potential novel targets for the treatment of inflammatory skin disorders. Human and mouse IL-36RN share 90% sequence identity.

Dettagli prodotto

• Codice: PKSM041482_100μg
• Marca: Elabscience
• Specie target: Mouse
• Host: E.coli
• Confezionamento: Lyophilized from sterile PBS, pH 7.4.<br/>Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.
• Link: Apri link
• Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
• Applicazione: Cell culture
• Simbolo target: IL-36RA
• Ig target: EBI;Interleukin;Il1f;Il1h;Il1hy;EBI3;EBV-induced gene 3 protein;Epstein-Barr virus-in duced gene 3 protein;IL-27-A;IL-27B;IL-30;Interleukin-27 subunit alpha;Interleukin-27 subunit beta;Interleukin-30;p28;Fil1d;Il1f5;Il1h3;Il1hy1;IL36RN