Human High-mobility group box 1 protein (HMGB1), previously known as HMG-1 or amphoterin, is a member of the high mobility group box family of non-histone chromosomal proteins. Human HMGB1 is expressed as a 30 kDa, 215 amino acid (aa) single chain polypeptide containing three domains: two N-terminal globular, 70 aa positively charged DNA-binding domains (HMG boxes A and B), and a negatively charged 30 aa C-terminal region that contains only Asp and Glu . Residues 27‑43 and 178‑184 contain a NLS. Posttranslational modifications of the molecule have been reported, with acetylation occurring on as many as 17 lysine residues.

Dettagli prodotto

• Codice: AN006010L_100μL
• Marca: Elabscience
• Specie target: Human;Mouse;Rat
• Host: Rabbit
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles. Protected from prolonged exposure to light.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: WB
• Diluizione: WB 1:500-1:1000
• Simbolo target: HMGB-1
• Ig target: High mobility group protein 1;high mobility group protein B1;high-mobility group box 1;HMG1;HMG-1;HMG1DKFZp686A04236;HMG3;HMGB1;SBP-1;Chromosomal protein;DKFZp686A04236;High mobility group 1;High mobility group box 1;high-mobility group (nonhistone chromosomal) protein 1;HMGB 1;nonhistone;NONHISTONE CHROMOSOMAL PROTEIN HMG1;SBP 1;Sulfoglucuronyl carbohydrate binding protein;SBP;HMGB;High Mobility Group Protein;High mobility group protein B;HMG;HMG-1;HMG1;HMG3;SBP-1;HMGB1;Amphoterin;High Mobility Group Protein 1;High mobility group protein B1;High mobility group protein 1 (HMG-1)
• Area di ricerca: Epigenetics and Nuclear Signaling