This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie1 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Dettagli prodotto

• Codice: AN200055P_100μL
• Marca: Elabscience
• Specie target: Human
• Host: Mouse
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
• Isotipo: IgG2b
• Clonalità: Monoclonal
• Clone: 9D4
• Coniugazione: Unconjugated
• Applicazione: IHC-P
• Diluizione: IHC-P 1:50-1:200;
• Simbolo target: Tie1
• Ig target: JTK;Tyrosine-Protein Kinase Receptor Tie;TIE1;JTK14;TIE;Tyrosine-Protein Kinase Receptor Tie-1;Tyrosine kinase with immunoglobulin-like and EGF-like domains 1
• Area di ricerca: Signal Transduction;Stem Cells;Cancer;Cardiovascular;Developmental Biology