SAE1 belongs to the ubiquitin-activating E1 family. It is a heterodimer that acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It functions as a UBLI E1 ligase mediating the ATP-dependent activation of UBL1. SAE1 binds with UBLE1A and UBLE1B to form a heterodimer which can bind UBL1. SAE1 also regulates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2. SAE1 and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins.

Dettagli prodotto

• Codice: AN200081P_100μL
• Marca: Elabscience
• Specie target: Human
• Host: Mouse
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
• Isotipo: IgG2b
• Clonalità: Monoclonal
• Clone: 2D8
• Coniugazione: Unconjugated
• Applicazione: ICC/IF
• Diluizione: ICC/IF 1:20-1:100;
• Simbolo target: SAE1
• Ig target: AOS;SUA;SAE;AOS1;SUA1;UBLE1A;SAE1;Activator of SUMO1;HSPC140;Sentrin/SUMO activating protein AOS1;SUMO 1 activating enzyme E1 N subunit;SUMO 1 activating enzyme subunit 1;SUMO-activating enzyme subunit 1;Ubiquitin like protein SUMO1 activating enzyme;Ubiquitin-like 1-activating enzyme E1A;UBL E1A
• Area di ricerca: Cell Biology