Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.

Dettagli prodotto

• Codice: AN200087P_100μL
• Marca: Elabscience
• Specie target: Human
• Host: Mouse
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
• Isotipo: IgG2b
• Clonalità: Monoclonal
• Clone: 5H10
• Coniugazione: Unconjugated
• Applicazione: WB
• Diluizione: WB 1:500-1:2000;
• Simbolo target: NRG1
• Ig target: NRG;MST;HRG1-beta;NRG1-beta;Pro-neuregulin;Neuregulin-1 beta;ARIA;EGF;GGF2;HRG;HRG1;HRG1-beta 1;MST131;Neuregulin-1 beta 1;NRG1-beta 1;Pro-neuregulin-1;GGF;HGL;HRGA;NDF;SMDF;NRG1;Acetylcholine receptor-inducing activity;alpha (45kD;Breast cancer cell differentiation factor p45;CHICK;ERBB2 p185-activator);Glial growth factor;Heregulin;homolog of;membrane-bound isoform;Neu differentiation factor;Neuregulin 1;neuregulin 1 type IV beta 1a;neuregulin 1 type IV beta 3;Neuregulin-1;NRG 1;NRG1-IT2;OTTHUMP00000225398;OTTHUMP00000225419;OTTHUMP00000225420;OTTHUMP00000225421;OTTHUMP00000225422;OTTHUMP00000225477;OTTHUMP00000225545;OTTHUMP00000230603;OTTHUMP00000230605;ProNRG1;Pro-NRG1;Sensory and motor neuron-derived factor
• Area di ricerca: Neuroscience