After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.

Dettagli prodotto

• Codice: AN300052P_100μL
• Marca: Elabscience
• Specie target: Human
• Host: Rabbit
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
• Isotipo: IgG
• Clonalità: Rabbit Monoclonal
• Clone: 2C8
• Coniugazione: Unconjugated
• Applicazione: IHC-P
• Diluizione: IHC-P 1:200-1:1000;
• Simbolo target: INS
• Ig target: MODY;IDDM;IDDM1;IDDM2;ILPR;IRDN;MODY10;INS;Insulin;Connecting Peptide;Insulin A chain;Insulin B chain;Preproinsulin;Proinsulin;Proinsulin precursor;IDDM;IDDM1;IDDM2;ILPR;ins;INS;Insulin A chain;Insulin B chain;IRDN;MODY10;Preproinsulin;Proinsulin;Proinsulin precursor;Pro-Insulin
• Area di ricerca: Signal Transduction;Neuroscience;Cardiovascular;Metabolism