The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.

Dettagli prodotto

• Codice: AN300083L_100μL
• Marca: Elabscience
• Specie target: Human
• Host: Rabbit
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
• Isotipo: IgG
• Clonalità: Rabbit Monoclonal
• Clone: 12G12
• Coniugazione: Unconjugated
• Applicazione: WB
• Diluizione: WB 1:2000-1:20000;
• Simbolo target: STAT6
• Ig target: D12S;STAT;Signal Transducer and Activator of Transcription;D12S1644;IL-4-STAT;STAT6B;STAT6C;STAT6;IL-4 Stat;Signal Transducer and Activator of Transcription 6;12S1644;IL 4 STAT;IL4 STAT;Interleukin 4 Induced;Interleukin 4 Induced Transcription Factor IL4 STAT;interleukin4 induced;Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced;Signal Transducer And Activator Of Transcription 6 Nirs Variant 1;STAT 6;STAT interleukin4 induced;Transcription factor IL 4 STAT
• Area di ricerca: Signal Transduction;Epigenetics and Nuclear Signaling;Cancer;Kits;Lysates;Other