ISG15 (interferon-induced 15 kDa protein; also known as IP17) is a 15 kDa ubiquitin family protein that is expressed by a wide variety of cell types. ISG15 is induced by type-I IFN, and like ubiquitin, becomes conjugated to intracellular proteins. Unlike ubiquitin, it does not target proteins for degradation. Instead, it is part of the antivirus response. Human proISG15 is 165 amino acids (aa) in length. There are two ubiquitin-like domains (aa 2-78 and 79-157) and a propeptide (aa 158-165) that is cleaved intracellularly. Select blood mononuclear cells secrete mature ISG15, which is chemotactic for neutrophils. Mature human ISG15 is 66% aa identical to mouse ISG15.

Dettagli prodotto

• Codice: AN300127P_100μL
• Marca: Elabscience
• Specie target: Human
• Host: Rabbit
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
• Isotipo: IgG
• Clonalità: Rabbit Monoclonal
• Clone: 5D9
• Coniugazione: Unconjugated
• Applicazione: WB;ICC/IF
• Diluizione: WB 1:2000-1:10000;ICC/IF 1:20-1:100;
• Simbolo target: ISG15
• Ig target: ISG;G1P;IFI;IMD;Ubiquitin-Like Protein ISG;ISG15;G1P2;IFI15;IMD38;IP17;UCRP;hUCRP;Interferon-Induced 15 kDa Protein;Interferon-induced 17 kDa protein;ISG15 ubiquitin-like modifier;Ubiquitin Cross-Reactive Protein;Ubiquitin-Like Protein ISG15;alpha-inducible protein (clone IFI-15K);IFI 15;Interferon;Interferon alpha inducible protein;Interferon induced protein 15;Interferon induced protein IFI-15K;Interferon stimulated protein 15 kDa;Interferon-induced 17-kDa/15-kDa protein;ISG 15;ISG15 ubiquitin like modifier
• Area di ricerca: Cell Biology;Epigenetics and Nuclear Signaling