BAFF, a member of the TNF superfamily of proteins, is a homotrimeric transmembrane protein, which is cleaved to produce a soluble cytokine. BAFF may also further oligomerize into 60-mer structures. BAFF is expressed by monocytes, neutrophils, macrophages, dendritic cells, activated T cells, and epithelial cells. BAFF plays a key role in B cell development, survival, and activation. BAFF binds to three distinct receptors, BAFF-R, TACI, and BCMA. These receptors are differentially expressed during B cell development and among B cell subsets. While BAFF-R and BCMA bind to the homotrimeric form of BAFF, TACI only binds to membrane bound or higher order BAFF structures. The BAFF/ BAFF-R interaction activates both canonical and non-canonical NF-κB pathways, PI3K/Akt, and mTOR. Activation of the noncanonical NF-κB pathway via BAFF-R is negatively regulated by TRAF3. Research studies have shown that elevated levels of BAFF may exacerbate many autoimmune disorders, making it a potential therapeutic target.

Dettagli prodotto

• Codice: AN300173P_100μL
• Marca: Elabscience
• Specie target: Human
• Host: Rabbit
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
• Isotipo: IgG
• Clonalità: Rabbit Monoclonal
• Clone: 7B3
• Coniugazione: Unconjugated
• Applicazione: WB;FCM;IP
• Diluizione: WB 1:500-1:2000;IP 1-4 μL/mg of lysate
• Simbolo target: TNFSF13B
• Ig target: UNQ;PRO;ZTNF;TNF- and APOL-related leukocyte expressed ligand;TNFSF;TNFSF13B;BAFF;BLYS;CD257;DTL;TALL-1;TALL1;THANK;TNFSF20;TNLG7A;ZTNF4;Tumor necrosis factor ligand superfamily member 13B;B lymphocyte stimulator;B-cell-activating factor;Dendritic cell-derived TNF-like molecule;TNF- and APOL-related leukocyte expressed ligand 1;UNQ401;PRO738;BAFF;TNFSF13b;TALL-1;ApoL related ligand TALL 1;B cell Activating Factor;CD 257;CD257 antigen;Delta BAFF;Dendritic cell derived TNF like molecule;DTL precursor;soluble form;TALL 1;TN13B;TNF and APOL related leukocyte expressed ligand 1;TNF homolog that activates apoptosis;TNF homolog that activates apoptosis NKFB and JNK.;Tumor necrosis factor (ligand) superfamily member 13b;Tumor necrosis factor ligand 7A;Tumor necrosis factor ligand superfamily member 20;Tumor necrosis factor like protein ZTNF4;Tumor necrosis factor superfamily member 13B
• Area di ricerca: Cell Biology;Immunology;Cancer