This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Dettagli prodotto

• Codice: AN300201P_20μL
• Marca: Elabscience
• Specie target: Human
• Host: Rabbit
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
• Isotipo: IgG
• Clonalità: Rabbit Monoclonal
• Clone: 8C3
• Coniugazione: Unconjugated
• Applicazione: FCM;ICC/IF
• Diluizione: ICC/IF 1:20-1:100;FCM 1:25-1:100;
• Simbolo target: TEK
• Ig target: TIE;TEK;CD202B;GLC3E;TIE-2;TIE2;VMCM;VMCM1;Tie2 (Tek);Angiopoietin 1 receptor;Angiopoietin-1 receptor;CD202b antigen;endothelial;Endothelial tyrosine kinase;Endothelium specific receptor tyrosine kinase 2;hTIE 2;hTIE2;Hyk;p140 TEK;Soluble TIE2 variant 1;Soluble TIE2 variant 2;tek tyrosine kinase;TEK tyrosine kinase endothelial;TIE 2;Tunica interna endothelial cell kinase;Tyrosine kinase with Ig and EGF homology domains 2;Tyrosine kinase with Ig and EGF homology domains-2;Tyrosine protein kinase receptor TEK;Tyrosine protein kinase receptor TIE 2;Tyrosine-protein kinase receptor TEK;Tyrosine-protein kinase receptor TIE-2;Venous malformations multiple cutaneous and mucosal;VMCM 1
• Area di ricerca: Signal Transduction;Cancer;Cardiovascular;Stem Cells;Developmental Biology