Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1-8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2.Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.Angiotensin-3 stimulates aldosterone release.Angiotensin 1-7 is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

Dettagli prodotto

• Codice: AN300213P_100μL
• Marca: Elabscience
• Specie target: Human
• Host: Rabbit
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
• Isotipo: IgG
• Clonalità: Rabbit Monoclonal
• Clone: 9A4
• Coniugazione: Unconjugated
• Applicazione: WB;FCM;ICC/IF;IP
• Diluizione: WB 1:500-1:2000;FCM 1:25-1:100;ICC/IF 1:20-1:100;IP 4-6 μL/mg of lysate
• Simbolo target: AGT
• Ig target: hFLT;Angiotensin 2;Angiotensin 3;AGT and SERPINA;SERPINA;Serpin A;AGT;ANHU;hFLT1;Aangiotensinogen;AGT and SERPINA8;Alpha 1 antiproteinase antitrypsin;Ang;ANGT;ANRT;AT-2;PAT;Angiotensinogen;Angiotensin-1;SERPINA8;Angiotensin-2;Angiotensin-3;Angiotensin-4;Serpin A8;Angiotensin 1-7;Angiotensin 1-10;Angiotensin I;Ang I;Angiotensin 1-8;Angiotensin II;Ang II;Angiotensin 2-8;Angiotensin III;Ang III;Angiotensin 3-8;Ang IV;Angiotensin 1-9;Angiotensin 1-5;Angiotensin 1-4;Angiotensin IV;Aangiotensinogen (serpin peptidase inhibitor clade A member 8);AI265500;Ang;AngII;Angiotensinogen (PAT);AT-II;Des-Asp[1]-angiotensin II;FLJ92595;FLJ97926;MGC105326;Pre angiotensinogen;Serine (or cysteine) proteinase inhibitor;Serpin peptidase inhibitor clade A member 8
• Area di ricerca: Cardiovascular;Signal Transduction;Metabolism;