EPH-related receptor tyrosine kinase ligand 1 (abbreviated as Ephrin-A1) also known as ligand of eph-related kinase 1 or EFNA1, is a member of the ephrin (EPH) family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin-A1/EFNA1 and its Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. An exception is the EphA4 receptor, which binds both subclasses of ephrins. Ephrin-A1 and one of its receptor EphA2 were expressed in xenograft endothelial cells and also tumor cells and play a role in human cancers, at least in part by influencing tumor neovascularization.

Dettagli prodotto

• Codice: AN300352P_100μL
• Marca: Elabscience
• Specie target: Human
• Host: Rabbit
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
• Isotipo: IgG
• Clonalità: Monoclonal
• Clone: 10F14
• Coniugazione: Unconjugated
• Applicazione: IHC-P
• Diluizione: IHC-P 1:100-1:500
• Simbolo target: EFNA1
• Ig target: EPLG;TNF Alpha-Induced Protein;Immediate Early Response Protein B;EPH-Related Receptor Tyrosine Kinase Ligand;Tumor Necrosis Factor Alpha-Induced Protein;EFNA;TNFAIP;Ephrin-A;EPH-Related Receptor Tyrosine Kinase Ligand 1;Ephrin-A1;Immediate Early Response Protein B61;LERK-1;TNF Alpha-Induced Protein 4;Tumor Necrosis Factor Alpha-Induced Protein 4;EPLG1;LERK1;TNFAIP4;EFNA1;B61;ECKLG;EFL 1;EFL1;EFNA 1;EPH related receptor tyrosine kinase ligand 1;Ephrin A1;EphrinA1;EPLG 1;LERK 1;Ligand of eph related kinase 1;OTTHUMP00000033242;OTTHUMP00000033271;secreted form;TNFAIP 4;Tumor necrosis factor alpha induced protein 4
• Area di ricerca: Cardiovascular;Neuroscience;Signal Transduction