65 is a subunit of the nuclear factor kappa B. The transcription factor NFkB is widely recognized as a critical mediator of immune and inflammatory responses. In most cell types, NFkB is found in the cytoplasm where it is associated with an inhibitory protein known as IkB. An impressive variety of stimuli (tumor necrosis factor, interleukin 1, T cell activation signals, bacterial endotoxins, viral transforming proteins, certain growth factors and reactive oxygen intermediates) lead to the rapid nuclear accumulation of NFkB by the induced phosphorylation and subsequent degradation of IkB.

Dettagli prodotto

• Codice: AN300381L_20μL
• Marca: Elabscience
• Specie target: Human
• Host: Rabbit
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
• Isotipo: IgG
• Clonalità: Monoclonal
• Clone: 11G4
• Coniugazione: Unconjugated
• Applicazione: WB
• Diluizione: WB 1:2000-1:20000
• Simbolo target: RELA
• Ig target: NFKB;Transcription factor p;Nuclear factor of kappa light polypeptide gene enhancer in B-cells;NF-kB p;NFKB3;p65;NF-kB p65;RELA;CMCU;Transcription factor p65;Nuclear factor NF-kappa-B p65 subunit;Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3;NFKB3;p65;transcription factor p65;Avian reticuloendotheliosis viral (v rel) oncogene homolog A;MGC131774;NF kappa B p65delta3;Nuclear Factor NF Kappa B p65 Subunit;Nuclear factor of kappa light polypeptide gene enhancer in B cells 3;OTTHUMP00000233473;OTTHUMP00000233474;OTTHUMP00000233475;OTTHUMP00000233476;OTTHUMP00000233900;p65 NF kappaB;p65 NFkB;TF65;V rel avian reticuloendotheliosis viral oncogene homolog A;v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65));V rel reticuloendotheliosis viral oncogene homolog A;v rel reticuloendotheliosis viral oncogene homolog A (avian)
• Area di ricerca: Cell Biology;Neuroscience;Microbiology;Signal Transduction;Epigenetics and Nuclear Signaling;Cancer;Cardiovascular;Metabolism