Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.

Dettagli prodotto

• Codice: AN300413P_100μL
• Marca: Elabscience
• Specie target: Human
• Host: Rabbit
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
• Isotipo: IgG
• Clonalità: Monoclonal
• Clone: 5D12
• Coniugazione: Unconjugated
• Applicazione: WB
• Diluizione: WB 1:500-1:2000
• Simbolo target: SNCA
• Ig target: Fetal liver kinase;Protein-tyrosine kinase receptor flk;Vascular endothelial growth factor receptor;PD1;NACP;PARK1;PARK4;SNCA;SNC-A;aSYN;CD309;Fetal liver kinase 1;FLK1;FLK-1;KDR;Kinase insert domain receptor;Protein-tyrosine kinase receptor flk-1;Vascular endothelial growth factor receptor 2;VEGFR;VEGFR2;VEGFR-2;Alpha-synuclein;Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor;PARK1;alpha (non A4 component of amyloid precursor);Alpha synuclein;alphaSYN;isoform NACP140;Lewy body) 4;MGC105443;MGC110988;MGC127560;MGC64356;Non A beta component of AD amyloid;Non A4 component of amyloid;Non A4 component of amyloid precursor;Non-A4 component of amyloid;Non-A-beta component of alzheimers disease amyloid;OTTHUMP00000218549;OTTHUMP00000218551;OTTHUMP00000218552;OTTHUMP00000218553;OTTHUMP00000218554;PARK 1;PARK 4;Parkinson disease (autosomal dominant;Parkinson disease familial 1;precursor of;Snca synuclein;SYN;Synuclein;Synuclein alpha;Synuclein alpha 140;SYUA
• Area di ricerca: Neuroscience