Fc receptors bind the most common class of antibody, IgG, are called Fc gamma receptors (FcγR). FcγR is divided into three classes, Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). CD16 protein is a multifunctional, low/intermediate affinity receptor, which belongs to the immunoglobulin superfamily. It is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. Mouse CD16 is encoded by a single gene, while, human CD16 is expressed as two distinct forms (CD16a/FcγRIIIa and CD16b/FcγRIIIb) encoded by two different highly homologous genes in a cell type-specific manner. CD16 is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), and clearance of immune complexes.
Stoccaggio: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Isotipo: IgG
Clonalità: Monoclonal
Clone: 9C1
Coniugazione: Unconjugated
Applicazione: WB;IP
Diluizione: WB 1:500-1:2000;IP 0.5-2 μL/mg of lysate
Simbolo target: FCGR3
Ig target: CD-antigen;Fcgr;CD16;CD16 Protein;CD-antigen 16;Fc gamma Receptor III;FcRIII;IgG Fc receptor III;Low affinity immunoglobulin gamma Fc region receptor III;Mouse;Fcgr3
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