The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).

Dettagli prodotto

• Codice: AN300883L_100μL
• Marca: Elabscience
• Specie target: Human;Mouse;Rat
• Host: Rabbit
• Concentrazione: 0.2 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG,κ
• Clonalità: Monoclonal;Recombinant
• Clone: 5C3
• Coniugazione: Unconjugated
• Applicazione: WB
• Diluizione: WB 1:2000-1:10000
• Simbolo target: eIF2α
• Ig target: EIF2S;EIF;EIF-2;EIF-2A;EIF-2alpha;EIF2;EIF2A;EIF2S1;EIF 2;EIF 2 alpha;EIF 2A;EIF 2alpha;EIF2 alpha;eIF-2-alpha;Eukaryotic translation initiation factor 2 subunit 1;Eukaryotic translation initiation factor 2 subunit 1 alpha;Eukaryotic translation initiation factor 2 subunit 1 alpha 35kDa;Eukaryotic translation initiation factor 2 subunit alpha;IF2A
• Area di ricerca: Epigenetics and Nuclear Signaling