TAR DNA binding protein(TARDBP) Homo sapiens HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.

Dettagli prodotto

• Codice: AN300963L_100μL
• Marca: Elabscience
• Specie target: Human;Mouse;Rat
• Host: Rabbit
• Concentrazione: 0.2 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG,κ
• Clonalità: Monoclonal;Recombinant
• Clone: 6F5
• Coniugazione: Unconjugated
• Applicazione: WB
• Diluizione: WB 1:1000-1:5000
• Simbolo target: TDP43
• Ig target: ALS;TDP;ALS10;TDP-43;TARDBP;TDP43;along with a truncated 20-28 kDa form;and 99% aa identity with rat TDP-43.;human and mouse TDP-43 share 100% aa sequence identity;in ubiquitin-containing inclusion bodies. TDP-43 can also influence CFTR exon 9 skipping in cystic fibrosis. Within aa 1-103;TDP-43 (TAR DNA binding protein of 43 kDa;TADBP
• Area di ricerca: Microbiology;Neuroscience;Epigenetics and Nuclear Signaling