This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.

Dettagli prodotto

• Codice: AN300974L_50μL
• Marca: Elabscience
• Specie target: Human;Mouse;Rat
• Host: Rabbit
• Concentrazione: 0.2 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG,κ
• Clonalità: Monoclonal;Recombinant
• Clone: 10A9
• Coniugazione: Unconjugated
• Applicazione: WB;IHC
• Diluizione: IHC 1:200-1:1000;WB 1:1000-1:5000
• Simbolo target: SIRT3
• Ig target: SIRT;SIR2L;sirtuin;SIRT3;SIR2L3;sirtuin 3;SIR2L3;sirtuin 3;hSIRT 3;hSIRT3;mitochondrial;Mitochondrial nicotinamide adenine dinucleotide dependent deacetylase;NAD dependent deacetylase sirtuin 3 mitochondrial;NAD-dependent protein deacetylase sirtuin-3;Regulatory protein SIR2 homolog 3;Silent mating type information regulation 2 S.cerevisiae homolog 3;Sir 2 like 3;SIR 2 like protein 3;SIR 3;SIR2 L3;Sir2 like 3;SIR2 like protein 3;SIR2-like protein 3;SIR3;SIRT 3;Sirtuin silent mating type information regulation 2 homolog 3 (S. cerevisiae);Sirtuin type 3;Sirtuin3
• Area di ricerca: Epigenetics and Nuclear Signaling;Cell Biology;Cancer;Cardiovascular;Metabolism