ATP + a protein = ADP + a phosphoprotein.,Promotes apoptosis and activation of NF-kappa-B. Required for TNFRSF1A mediated activation of NF-kappa-B.,PTM:Autophosphorylated on serine and threonine residues.,PTM:Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation and enhances pro-apototic signaling through the TRADD-FADD interaction.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 death domain.,similarity:Contains 1 protein kinase domain.,subunit:Binds to the death domain of TNFRSF6 and TRADD. Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RIPK3, UBCE7IP1 isoform 3 (ZIN), EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interacts with MAVS/IPS1.

Dettagli prodotto

• Codice: AN301086L_50μL
• Marca: Elabscience
• Specie target: Human
• Host: Rabbit
• Concentrazione: 0.2 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG,κ
• Clonalità: Monoclonal;Recombinant
• Clone: 6G10
• Coniugazione: Unconjugated
• Applicazione: WB;IHC
• Diluizione: IHC 1:200-1000;WB 1:1000-5000
• Simbolo target: RIP
• Ig target: RIPK;RIP;RIP-1;RIP1;RIPK1;Cell death protein RIP;FLJ39204;OTTHUMP00000039163;Receptor (TNFRSF) interacting serine threonine kinase 1;Receptor interacting protein;receptor interacting protein 1;Receptor interacting protein kinase 1;Receptor interacting serine threonine protein kinase 1;Receptor TNFRSF interacting serine threonine kinase 1;Receptor-interacting protein 1;Receptor-interacting serine/threonine-protein kinase 1;Rinp;RIP 1;RIPK 1;Serine threonine protein kinase RIP;Serine/threonine-protein kinase RIP;RIPK1
• Area di ricerca: Cell Biology;Signal Transduction;Cancer