After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.

Dettagli prodotto

• Codice: AN301325L_100μL
• Marca: Elabscience
• Specie target: Human;Mouse;Rat
• Host: Rabbit
• Concentrazione: 0.2 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG,κ
• Clonalità: Monoclonal;Recombinant
• Clone: 9C4
• Coniugazione: Unconjugated
• Applicazione: WB
• Diluizione: WB 1:1000-1:5000
• Simbolo target: Insulin
• Ig target: MODY;IDDM;IDDM1;IDDM2;ILPR;IRDN;MODY10;INS;Insulin;Connecting Peptide;Insulin A chain;Insulin B chain;Preproinsulin;Proinsulin;Proinsulin precursor;IDDM;IDDM1;IDDM2;ILPR;ins;INS;Insulin A chain;Insulin B chain;IRDN;MODY10;Preproinsulin;Proinsulin;Proinsulin precursor;Pro-Insulin
• Area di ricerca: Signal Transduction;Neuroscience;Cardiovascular;Metabolism