This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.

Dettagli prodotto

• Codice: AN301373L_100μL
• Marca: Elabscience
• Specie target: Human;Mouse;Rat
• Host: Rabbit
• Concentrazione: 0.2 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG,κ
• Clonalità: Monoclonal;Recombinant
• Clone: 6F2
• Coniugazione: Unconjugated
• Applicazione: WB
• Diluizione: WB 1:1000-1:5000
• Simbolo target: TGF β Receptor II
• Ig target: MFS;LDS;FAA;AAT;TAAD;TGFR;TGF-beta receptor type;TGFBR;AAT3;FAA3;LDS1B;LDS2;LDS2B;MFS2;RIIC;TAAD2;TGFR-2;TGFbeta-RII;TGF beta Receptor II;TGFBR2;TGF-beta receptor type-2;TGF-beta type II receptor;Transforming growth factor-beta receptor type II;FAA3;LDS1B;LDS2;LDS2B;MFS2;RIIC;TAAD2;Tgfbr2;beta receptor II (70/80kDa);beta receptor II alpha;beta receptor II beta;beta receptor II delta;beta receptor II epsilon;beta receptor II gamma;TbetaR II;TbetaR-II;TBRII;TBR-ii;TGF beta receptor type 2;TGF beta receptor type II;TGF beta receptor type IIB;TGF beta type II receptor;TGFB R2;TGFbeta - RII;TGF-beta receptor type II;TGFbeta RII;TGF-beta-R2;TGFR2;Transforming growth factor;transforming growth factor beta receptor 2;Transforming growth factor beta receptor II;Transforming growth factor beta receptor type II;Transforming growth factor beta receptor type IIC
• Area di ricerca: Signal Transduction;Stem Cells