Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.Calcium is required for ligand binding.
Ig target: ASGR;C type lectin domain family 4 member H;CLEC4H;ASGP-R;ASGR1;ASGPR;ASGPR1;CLEC4H1;HL-1;ASGPR 1;ASGP-R 1;Asialoglycoprotein receptor 1;C type lectin domain family 4 member H1;C-type lectin domain family 4 member H1;Hepatic lectin H1
Area di ricerca:Signal Transduction;Tags & Cell Markers
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