Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). Plays a role in the lineage differentiation of the germ layers in embryonic development. Involved in sexual development, acting as activator of NR5A1 expression.

Codice: AN301458L_100μL | Marca: Elabscience | Confezionamento: 100μL

Specie: Human;Rat;MouseIsotipo: IgG,κClone: A153Coniugazione: Unconjugated
Dettagli prodotto
  • Codice: AN301458L_100μL
  • Marca: Elabscience
  • Specie target: Human;Rat;Mouse
  • Host: Rabbit
  • Concentrazione: 1 mg/mL
  • Link: Apri link
  • Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
  • Isotipo: IgG,κ
  • Clonalità: Monoclonal;Recombinant
  • Clone: A153
  • Coniugazione: Unconjugated
  • Applicazione: WB
  • Diluizione: WB 1:500-1:1000
  • Simbolo target: CBX2
  • Ig target: CBX;CDCA;SRXY;CBX2;CDCA6;M33;SRXY5
  • Area di ricerca: Epigenetics and Nuclear Signaling