Integrin α-IIb/β-3 (ITGA2B) is a cell surface adhesion molecule that is the receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. In activated platelets, ITGA2B can be cleaved by proteolytic enzymes to generate disulfide bond-connected heavy and light chains, and form fibrinogen receptors together with glycoprotein IIIb, causing platelet interactions and rapid platelet aggregation, thereby Block the surface of ruptured endothelial cells. The corresponding ITGA2B gene mutation can cause platelet weakness.
