Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement.

Dettagli prodotto

• Codice: AN301629L_50μL
• Marca: Elabscience
• Specie target: Human;Mouse
• Host: Rabbit
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG,κ
• Clonalità: Monoclonal;Recombinant
• Clone: A332
• Coniugazione: Unconjugated
• Applicazione: IHC;IF
• Diluizione: IHC 1:50-1:100;IF 1:50
• Simbolo target: PI3 Kinase p85 alpha
• Ig target: GRB;IMD;AGM;PIK3R;AGM7;GRB1;IMD36;p85;p85-ALPHA;PI3 Kinase p85 alpha;PIK3R1;p85 alpha;P85A;Phosphatidylinositol 3 kinase;Phosphatidylinositol 3 kinase associated p 85 alpha;Phosphatidylinositol 3 kinase regulatory 1;Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha;Phosphatidylinositol 3-kinase regulatory subunit alpha;Phosphoinositide 3 kinase;PI3 kinase p85 subunit alpha;PI3K;PI3K regulatory subunit alpha;PI3-kinase regulatory subunit alpha;PI3-kinase subunit p85-alpha;polypeptide 1 (p85 alpha);PtdIns 3 kinase p85 alpha;PtdIns-3-kinase regulatory subunit alpha;PtdIns-3-kinase regulatory subunit p85-alpha;regulatory subunit;regulatory subunit 1 (alpha)
• Area di ricerca: Signal Transduction;Cancer;Immunology;Metabolism