Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors.

Dettagli prodotto

• Codice: AN301630L_100μL
• Marca: Elabscience
• Specie target: Human;Rat;Mouse
• Host: Rabbit
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG,κ
• Clonalità: Monoclonal;Recombinant
• Clone: A333
• Coniugazione: Unconjugated
• Applicazione: WB;IHC;IF
• Diluizione: WB 1:500-1:2000;IHC 1:200-1:1000;IF 1:50
• Simbolo target: PI3 Kinase p110 alpha
• Ig target: CWS;PIK3CA;CLOVE;CWS5;MCAP;MCM;MCMTC;PI3K;PI3K-alpha;5 bisphosphate 3 kinase 110 kDa catalytic subunit alpha;5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha;5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha (PtdIns-3-kinase subunit p110-alpha;5-bisphosphate 3-kinase catalytic subunit alpha isoform;caPI3K;MGC142161;MGC142163;p110 alpha;p110alpha;Phosphatidylinositol 3 kinase catalytic 110 KD alpha;Phosphatidylinositol 3 kinase catalytic alpha polypeptide;Phosphatidylinositol 4;Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha;Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform;Phosphatidylinositol-4;Phosphoinositide 3 kinase catalytic alpha polypeptide;Phosphoinositide 3-kinase alpha;Phosphoinositide-3-kinase catalytic alpha polypeptide;PI3 kinase p110 subunit alpha;PI3Kalpha;PI3KC A;PI3-kinase subunit alpha;PIK3C A;PK3CA;PtdIns 3 kinase p110;PtdIns-3-kinase subunit alpha;PtdIns-3-kinase subunit p110-alpha;Serine/threonine protein kinase PIK3CA
• Area di ricerca: Signal Transduction;Cancer;Immunology