Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules.Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha .At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation.

Dettagli prodotto

• Codice: AN301679L_50μL
• Marca: Elabscience
• Specie target: Human;Rat;Mouse
• Host: Rabbit
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG,κ
• Clonalità: Monoclonal;Recombinant
• Clone: A382
• Coniugazione: Unconjugated
• Applicazione: IHC;IF;FCM;WB
• Diluizione: WB 1:500-1:1000;IHC 1:50-1:200;IF 1:50;FCM 1:50-1:100
• Simbolo target: TPX2
• Ig target: FLS;HCA;TPX;HCTP;REPP;GD:C20orf;DIL;DIL2;p100;DIL-2;HCTP4;FLS353;HCA519;REPP86;C20orf1;C20orf2;GD:C20orf1;TPX2;Chromosome 20 Open Reading Frame 1;Differentially expressed in cancerous and noncancerous lung cells 2;Differentially expressed in cancerous and non-cancerous lung cells 2;Differentially expressed in lung cells;Differentially expressed in lung cells 2;DIL 2;HCA 519;HCTP 4;Hepatocellular carcinoma associated antigen 519;Hepatocellular carcinoma-associated antigen 519;Preferentially expressed in colorectal cancer;Protein fls353;REPP 86;Restricted expression proliferation associated protein 100;Restricted expression proliferation-associated protein 100;Targeting protein for Xklp2;TPX 2;TPX2 microtubule associated homolog;TPX2 microtubule associated protein homolog;TPX2 microtubule nucleation factor
• Area di ricerca: Cell Biology;Epigenetics and Nuclear Signaling;Cancer