Human VIPR2 (Vasoactive Intestinal Polypeptide Receptor 2), also known as VPAC2, is a 60-70 kDa seven transmembrane glycoprotein receptor, which belongs to the G protein-coupled receptor 2 family of proteins. In its first extracellular region hormone receptor domain (aa 49-114) contains a mature chain, which has three N-linked glycosylation sites and a "Cilia targeting signal", which is composed of and Arg -Composition of Asp-Tyr-Arg sequence. Human VIPR2 has relatively high homology with mouse and rat VIPR2. VIPR2 is mainly expressed in skeletal muscle, CD4+ T cells, smooth muscle cells, dendritic cells, liver precursor cells, single cells, synthetic cells and selective neurons. VIPR2 couples with CAMP-mediated signal transduction pathways, and binds VIP and pituitary adenase activating polypeptide (PACAP).
