MRP8/S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. MRP8 has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration.

Dettagli prodotto

• Codice: AN301719L_50μL
• Marca: Elabscience
• Specie target: Human;Rat;Mouse
• Host: Rabbit
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG,κ
• Clonalità: Monoclonal;Recombinant
• Clone: A427
• Coniugazione: Unconjugated
• Applicazione: WB;IHC;FCM
• Diluizione: WB 1:500-1:1000;IHC 1:200-1:1000;FCM 1:50-1:100
• Simbolo target: S100A8
• Ig target: Protein S100-A;S100a;Kcnip;KCHIP;MRP;S100A8;60B8AG;CAGA;CFAG;CGLA;CP-10;L1Ag;MA387;MIF;MRP8;NIF;P8;Calgranulin A;Calgranulin-A;Cystic fibrosis antigen;Leukocyte L1 complex light chain;MRP-8;Protein S100-A8;CALP;KCNIP4;KCHIP4;AI323541;B8Ag;BEE11;Calprotectin;Calprotectin L1L subunit;Chemotactic cytokine CP-10;included;Migration inhibitory factor-related protein 8;Myeloid-related protein 8;Neutrophil cytosolic 7 kDa protein;Pro-inflammatory S100 cytokine;S100 calcium binding protein A8;S100 calcium binding protein A8 (calgranulin A);S100 calcium-binding protein A8;S100A8/S100A9 complex;S10A8;Urinary stone protein band A
• Area di ricerca: Neuroscience;Cancer;Immunology;Signal Transduction;Cell Biology;Epigenetics and Nuclear Signaling