LILRB1 is a member of the leukocyte immunoglobulin-like receptor (LIR) family. This protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.
Ig target: LILRB;ILT;LIR;MIR;LILRB1;CD85J;ILT-2;ILT2;LIR-1;LIR1;MIR-7;MIR7;PIR-B;PIRB;ILT2;LILRB1;CD85;CD85 antigen;CD85 antigen like family member J;CD85 antigen-like family member J;CD85j antigen;Ig like transcript 2;ILT 2;immunoglobulin like transcript 2;Immunoglobulin-like transcript 2;leukocyte Ig like receptor 1;leukocyte immunoglobulin like receptor;Leukocyte immunoglobulin like receptor 1;leukocyte immunoglobulin like receptor subfamily B member 1;Leukocyte immunoglobulin like receptor subfamily B member 1 precursor;leukocyte immunoglobulin like receptor subfamily B member 1 soluble isoform;leukocyte immunoglobulin-like receptor;Leukocyte immunoglobulin-like receptor 1;Leukocyte immunoglobulin-like receptor subfamily B member 1;leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform;LIR 1;LIRB1;member 1;MIR 7;Monocyte/macrophage immunoglobulin like receptor 7;Monocyte/macrophage immunoglobulin-like receptor 7;PIR B;subfamily B;subfamily B (with TM and ITIM domains)
Area di ricerca:Immunology
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