The Akt/PKB family of kinases, Akt1, -2, and -3, plays critical roles in regulating growth, proliferation, survival, metabolism, and other cellular activities. Akt kinases control these activities by phosphorylation-mediated regulation of multiple substrates. Deregulated, or enhanced, Akt signaling has also been implicated in a variety of human cancers, and may promote tumorigenesis.
