Chicken ovalbumin upstream promoter transcription factor (COUP-TF) belongs to the NR2 subfamily of the nuclear hormone receptor family. COUP-TFI and COUP-TFII are two of the well-characterized members in the NR2 subfamily. These two members are highly conserved in their two zinc-finger DNA binding domains (DBD) and the ligand binding domain (LBD), and function as repressors or activators of downstream target genes to regulate different biological processes. COUP-TFI and II bind to 5'-AGGTCA-3' motif palindromes, either directly or indirectly, through heterodimer formation with other proteins (e.g. RXRs) to regulate downstream target gene expression. COUP-TFI is involved in neuronal development, tissue patterning, and differentiation. COUP-TFII has been shown to be involved in angiogenesis, glucose homeostasis, and mesenchymal cell commitment.

Dettagli prodotto

• Codice: AN301980L_100μL
• Marca: Elabscience
• Specie target: Human;Rat;Mouse
• Host: Rabbit
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG,κ
• Clonalità: Monoclonal;Recombinant
• Clone: A696
• Coniugazione: Unconjugated
• Applicazione: WB;IHC;ChIP
• Diluizione: WB 1:500-1:1000;IHC 1:50-1:100;ChIP 6μg/2×10⁶cells
• Simbolo target: COUP-TFII
• Ig target: SVP;COT;CHTD;NF-E;COUP transcription factor;Apolipoprotein AI regulatory protein;Apolipoprotein A-I regulatory protein;Nuclear receptor subfamily 2 group F member;TFCOUP;COUP TF;COUP-TF;ARP;NR2F2;ARP1;CHTD4;COUPTFB;COUPTFII;NF-E3;SVP40;TFCOUP2;Apolipoprotein AI regulatory protein 1;Apolipoprotein A-I regulatory protein 1;ARP-1;COT2;COUP TF2;COUP transcription factor 2;COUP transcription factor II;COUP-TF II;COUP-TF2;NR2F1;Nuclear receptor subfamily 2 group F member 2
• Area di ricerca: Cardiovascular;Cell Biology;Neuroscience;Epigenetics and Nuclear Signaling;Signal Transduction;Cancer;Metabolism