The protein is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade.

Dettagli prodotto

• Codice: AN302084L_100μL
• Marca: Elabscience
• Specie target: Human;
• Host: Rabbit
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG,κ
• Clonalità: Monoclonal;Recombinant
• Clone: A808
• Coniugazione: Unconjugated
• Applicazione: WB
• Diluizione: WB 1:500-1:2000
• Simbolo target: Phospho-FADD (S194)
• Ig target: GIG;MORT;FADD;GIG3;MORT1;Fas associated via death domain;FADD protein;Fas (TNFRSF6) associated via death domain;Fas associating death domain containing protein;Fas associating protein;Fas associating protein with death domain;Fas TNFRSF6 associated via death domain;FAS-associated death domain protein;FAS-associating death domain-containing protein;GIG 3;Growth inhibiting gene 3 protein;Growth-inhibiting gene 3 protein;H sapiens mRNA for mediator of receptor induced toxicity;Mediator of receptor induced toxicity;MGC8528;MORT 1;Protein FADD
• Area di ricerca: Cell Biology;Cancer