Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.

Codice: E-AB-10614_60μL | Marca: Elabscience | Confezionamento: 60μL

Specie: Human;MouseIsotipo: IgGConiugazione: Unconjugated

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Codice: E-AB-10614_60μL
Marca: Elabscience
Specie target: Human;Mouse
Host: Rabbit
Concentrazione: 0.2 mg/mL
Link: Apri link
Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
Isotipo: IgG
Clonalità: Polyclonal
Coniugazione: Unconjugated
Applicazione: WB
Diluizione: WB 1:500-1:2000
Simbolo target: SPDL1
Ig target: AA409762;Arsenite related gene 1 protein;Arsenite-related gene 1 protein;CCDC 99;Ccdc99;Coiled coil domain containing 99;Coiled-coil domain-containing protein 99;FLJ20364;FLJ40690;hSpindly;MGC124977;Protein Spindly;rhabdomyosarcoma antigen MU RMS 40.4A;Rhabdomyosarcoma antigen MU-RMS-40.4A;Rrhabdomyosarcoma antigen protein MU RMS 40.4A;SPDL1;SPDLY;Spindle apparatus coiled coil domain containing protein 1;Spindle apparatus coiled coil protein 1;Spindly;Spindly homolog
Area di ricerca: Cell Biology

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