Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.

Dettagli prodotto

• Codice: E-AB-10851_60μL
• Marca: Elabscience
• Specie target: Human;Mouse
• Host: Rabbit
• Concentrazione: 0.2 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: IHC
• Diluizione: IHC 1:50-1:200
• Simbolo target: SETD2
• Ig target: EC 2.1.1.43;FLJ16420;FLJ22472;FLJ23184;FLJ45883;HBP231;HIF 1;HIF-1;HIF1;HIP-1;Histone lysine N methyltransferase SETD2;Histone-lysine N-methyltransferase SETD2;hSET2;HSPC069;Huntingtin interacting protein 1;Huntingtin interacting protein;Huntingtin interacting protein B;Huntingtin interacting protein HYPB;Huntingtin yeast partner B;Huntingtin-binding protein;231-KD;Huntingtin-interacting protein 1;Huntingtin-interacting protein B;HYPB;KIAA1732;KMT3A;Lysine N methyltransferase 3A;Lysine N-methyltransferase 3A;p231HBP;SET domain containing 2;SET domain-containing protein 2;SET2;SETD2;SETD2
• Area di ricerca: Cancer;Epigenetics and Nuclear Signaling