Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.

Codice: E-AB-12757_200μL | Marca: Elabscience | Confezionamento: 200μL

Specie: Human;MouseIsotipo: IgGConiugazione: Unconjugated

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Codice: E-AB-12757_200μL
Marca: Elabscience
Specie target: Human;Mouse
Host: Rabbit
Concentrazione: 0.3 mg/mL
Link: Apri link
Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
Isotipo: IgG
Clonalità: Polyclonal
Coniugazione: Unconjugated
Applicazione: IHC
Diluizione: IHC 1:25-1:100
Simbolo target: SMG8
Ig target: ABC 2;ABC2;Amplified in breast cancer gene 2 protein;Chromosome 17 open reading;chromosome 17 open reading frame 71;FLJ10587;Protein smg 8 homolog;protein SMG8;SMG8;SMG8 protein
Area di ricerca: Cancer

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