Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones

Dettagli prodotto

• Codice: E-AB-12793_60μL
• Marca: Elabscience
• Specie target: Human
• Host: Rabbit
• Concentrazione: 0.5 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: IHC
• Diluizione: IHC 1:50-1:200
• Simbolo target: MYSM1
• Ig target: 2A-DUB;2ADUB;Histone H2A deubiquitinase;Histone H2A deubiquitinase MYSM1;KIAA1915;Myb like SWIRM and MPN domains 1;Myb like;SWIRM and MPN domain containing protein;Myb like;SWIRM and MPN domains 1;Myb-like;Myb-like;SWIRM and MPN domains 1;MYSM 1;mysm1;MYSM1 Myb-like;SWIRM and MPN domains 1;MYSM1;RP4-592A1.1;SWIRM and MPN domain-containing protein 1
• Area di ricerca: Cancer;Epigenetics and Nuclear Signaling