Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.

Codice: E-AB-12938_200μL | Marca: Elabscience | Confezionamento: 200μL

Specie: Human;Mouse;RatIsotipo: IgGConiugazione: Unconjugated

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Codice: E-AB-12938_200μL
Marca: Elabscience
Specie target: Human;Mouse;Rat
Host: Rabbit
Concentrazione: 0.4 mg/mL
Link: Apri link
Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
Isotipo: IgG
Clonalità: Polyclonal
Coniugazione: Unconjugated
Applicazione: IHC
Diluizione: IHC 1:50-1:200
Simbolo target: ACO1
Ig target: ACO 1;ACO1;ACOC;Aconitase 1 soluble;Aconitase;Aconitase1;Aconitate hydratase;ACONS;Citrate hydro lyase;Citrate hydro-lyase;Cytoplasmic aconitate hydratase;Ferritin repressor protein;IRE BP 1;IRE-BP 1;IREB 1;IREB1;IREBP;IREBP1;Iron regulatory protein 1;Iron responsive element binding protein 1;Iron-responsive element-binding protein 1;IRP 1;IRP1;OTTHUMP00000045233
Area di ricerca: Cancer;Cardiovascular;Epigenetics and Nuclear Signaling;Metabolism;Signal Transduction

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