This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome.

Dettagli prodotto

• Codice: E-AB-13109_20μL
• Marca: Elabscience
• Specie target: Human
• Host: Rabbit
• Concentrazione: 0.8 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: IHC
• Diluizione: IHC 1:50-1:200
• Simbolo target: NOD2
• Ig target: ACUG;Arthrocutaneouveal granulomatosis;BLAU;CARD15;Caspase recruitment domain family;member 15;Caspase recruitment domain protein 15;Caspase recruitment domain-containing protein 15;CD;CLR16.3;IBD1;Inflammatory bowel disease protein 1;LRR containing protein;NLR family;CARD domain containing 2;NLRC2;NOD like receptor C2;NOD2;NOD2 protein;NOD2;NOD2B;nucleotide binding oligomerization domain 2;Nucleotide binding oligomerization domain containing 2;Nucleotide binding oligomerization domain;leucine rich repeat and CARD domain containing 2;Nucleotide-binding oligomerization domain-containing protein 2;PSORAS1
• Area di ricerca: Cancer;Cell Biology