Factor inhibiting HIF-1 (FIH-1) exists as a homodimer and binds to HIF-1alpha. Specifically, FIH-1 operates as an asparaginyl hydroxylase. It catalyzes the hydroxylation of the beta-carbon of Asparagine residue 803 within the carboxy terminal transactivation domain of HIF-1alpha. This hydroxylation event blocks the association of HIF-1alpha with co-activators. FIH-1 also binds to von Hippel-Lindau (VHL) tumor suppressor protein, which represses transcriptional ac-tivity of HIF-1alpha. In transiently transfected human osteosarcoma cells, FIH-1 localizes to the cytoplasm.

Dettagli prodotto

• Codice: E-AB-13556_20μL
• Marca: Elabscience
• Specie target: Human;Mouse
• Host: Rabbit
• Concentrazione: 0.6 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: WB;IHC
• Diluizione: WB 1:500-1:2000;IHC 1:50-1:300
• Simbolo target: HIF1AN
• Ig target: DKFZp762F1811;Factor inhibiting HIF-1;Factor inhibiting HIF1;FIH 1;FIH-1;FIH1;FLJ20615;FLJ22027 ;HIF1AN;HIF1N;Hypoxia inducible factor 1 alpha inhibitor;Hypoxia inducible factor 1 alpha subunit inhibitor;Hypoxia inducible factor asparagine hydroxylase;Hypoxia-inducible factor 1-alpha inhibitor;Hypoxia-inducible factor asparagine hydroxylase;Peptide aspartate beta dioxygenase
• Area di ricerca: Cancer;Epigenetics and Nuclear Signaling