Rapamycin-insensitive companion of mTORis aproteinthat in humans is encoded by theRICTORgene. RICTOR and MTOR are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth. Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors.

Dettagli prodotto

• Codice: E-AB-14684_120μL
• Marca: Elabscience
• Specie target: Human;Mouse
• Host: Rabbit
• Concentrazione: 0.3 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: IHC
• Diluizione: IHC 1:50-1:200
• Simbolo target: RICTOR
• Ig target: AVO3;AVO3 homolog;DKFZp686B11164;hAVO3;KIAA1999;Likely ortholog of mouse TORC2 specific protein AVO3 (S. cerevisiae);mAVO3;MGC39830;PIA;Pianissimo;Rapamycin insensitive companion of mTOR;Rapamycin-insensitive companion of mTOR;Rictor;RICTR;RICTR;RPTOR independent companion of MTOR complex 2;TORC2 specific protein AVO3
• Area di ricerca: Cancer;Cell Biology;Signal Transduction