E1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme, binds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. EID-1 also acetylates both histones and non-histone proteins such as NCOA3 co-activator. By acetylating histones, EID-1 gives a specific tag for transcriptional activation. In addition to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP responsive genes as a co-activator.

Dettagli prodotto

• Codice: E-AB-14978_200μL
• Marca: Elabscience
• Specie target: Human
• Host: Rabbit
• Concentrazione: 0.6 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: IHC
• Diluizione: IHC 1:50-1:200
• Simbolo target: EID1
• Ig target: 21 kDa pRb associated protein;21 kDa pRb-associated protein;C15orf3;CBP;Chromosome 15 open reading frame 3;CREBBP/EP300 inhibitor 1;CREBBP/EP300 inhibitory protein 1;CRI 1;CRI1;E1A like inhibitor of differentiation;E1A-like inhibitor of differentiation 1;EID 1;EID-1;EID1;EID1;EP300 interacting inhibitor of differentiation 1;EP300-interacting inhibitor of differentiation 1;IRO45620;MGC138883;MGC138884;NB4 apoptosis related protein;PNAS 22;PNAS22;PTD014;Rb and p300 binding protein EID 1;Rb and p300 binding protein EID1;RBP21;Retinoblastoma protein associated protein
• Area di ricerca: Cancer;Cell Biology;Epigenetics and Nuclear Signaling;Signal Transduction