The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene.

Dettagli prodotto

• Codice: E-AB-15187_20μL
• Marca: Elabscience
• Specie target: Human;Mouse
• Host: Rabbit
• Concentrazione: 0.2 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: WB;IHC
• Diluizione: WB 1:200-1:1000;IHC 1:50-1:200
• Simbolo target: TAB3
• Ig target: MAP3K7IP 3;Mitogen-activated protein kinase kinase kinase 7-interacting protein 3;NAP1;NF-kappa-B-activating protein 1;NFkB activating protein 1;TAB-3;Tab3;TAB3;TAK1 binding protein 3;TAK1-binding protein 3;TGF-beta-activated kinase 1 and MAP3K7-binding protein 3;TGF-beta-activated kinase 1-binding protein 3
• Area di ricerca: Cancer;Epigenetics and Nuclear Signaling;Immunology;Signal Transduction