PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.

Codice: E-AB-15225_60μL | Marca: Elabscience | Confezionamento: 60μL

Specie: Human;MouseIsotipo: IgGConiugazione: Unconjugated

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Codice: E-AB-15225_60μL
Marca: Elabscience
Specie target: Human;Mouse
Host: Rabbit
Concentrazione: 0.1 mg/mL
Link: Apri link
Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
Isotipo: IgG
Clonalità: Polyclonal
Coniugazione: Unconjugated
Applicazione: WB
Diluizione: WB 1:500-1:2000
Simbolo target: PLEKHG6
Ig target: FLJ10665;MGC126315;MGC126353;MGC126354;Myosin interacting guanine nucleotide exchange factor;PH domain containing family G member 6;Pleckstrin homology domain containing family G (with RhoGef domain) member 6;Pleckstrin homology domain-containing family G member 6;PLEKHG6
Area di ricerca: Cancer;Cell Biology;Signal Transduction

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